Complex of human neutrophil elastase with 1/2SLPI
نویسندگان
چکیده
منابع مشابه
Complex of human neutrophil elastase with 1/2SLPI
SLPI (secretory leukocyte protease inhibitor) is a 107-residue non-glycosylated protease inhibitor, which inhibits a wide range of serine proteases, trypsin, chymotrypsin, neutrophil elastase, chymase and cathepsin G. X-ray crystallographic analyses have shown that SLPI comprises two separate domains of similar architecture [Grütter, Fendrich, Huber & Bode (1988), EMBO J. 7, 345-351] and the C-...
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During blood coagulation human polymorphonuclear leukocytes release elastase in amounts that can exceed 100 nmol/liter. We therefore studied the effect of elastase on platelet structure and function. Physiologic concentrations of elastase specifically inhibited thrombin-induced platelet aggregation and ristocetininduced agglutination of washed platelets in a timeand dosedependent manner. This w...
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ژورنال
عنوان ژورنال: Journal of Synchrotron Radiation
سال: 2008
ISSN: 0909-0495
DOI: 10.1107/s0909049507060670